The main website is back, in a way. Greg decided to start up a podcast series to discuss issues around bioinformatics and I guess whatever else he might be interested in. Go check it out. The first episode is a conversation with Neil Saunders, one of Nodalpoint's early users (blog, friendfeed, twitter) .
Among many other things, they talk about the lack of traction that open science has among scientists. I agree with some of the points that were raised regarding the small size niche of each specific research problem. It is not the full answer but it probably plays a role. There are so few people that have the skills and interest to tackle the same problem that creating a online community around any given scientific question becomes hard. Still, if we have not come together to openly share results and methods we have at least witness the creation of many online communities that are working very well to discuss all sort of different scientific issues (ex. Friendfeed-Life Scientists, Biostart, Nature Network, etc).